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The activity and expression of NRF2 were decreased in many AKI and CKD animal models, suggesting that NRF2 was an important mediator in the pathogenesis and progression of AKI and CKD [204, 205]

Tauroursodeoxycholic acid attenuates inorganic phosphate-induced osteoblastic differentiation and mineralization in NIH3T3 fibroblasts by inhibiting the ER stress response PERK-eIF2-ATF4 pathway